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Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 263-274 doi: 10.1007/s11684-012-0215-5

Abstract:

Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.

Keywords： DNA double strand breaks     chromosomal translocations     genomic instability     spatial proximity     carcinogenesis    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract: Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancerradicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomicFurthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extentof genomic instability in primary VX2 tumor tissue.Taken together, our data suggest that the genomic protector AET can inhibit the induction of SLCCs, and

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract:

Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 268-278 doi: 10.15302/J-FASE-2017164

Abstract: Genomic selection is becoming increasingly important in animal and plant breeding, and is attractingthe most commonly used statistical methods and some extensions of them, i.e., ridge regression and genomicIn simulation studies where true breeding values are available, accuracy of genomic estimated breedingFactors influencing the accuracy of genomic selection include linkage disequilibrium between markersGenomic selection has been implemented in the breeding programs of dairy cattle, beef cattle, pigs and

Keywords： genomic estimated breeding value     genomic selection     linkage disequilibrium     statistical methods    

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Combustion instability detection using the wavelet detail of pressure fluctuations

JI Junjie, LUO Yonghao

Frontiers in Energy 2008, Volume 2, Issue 1,   Pages 116-120 doi: 10.1007/s11708-008-0019-0

Abstract: A combustion instability detection method that uses the wavelet detail of combustion pressure fluctuations

Keywords： comparison     wavelet approximation     pressure transducer     general pressure     consistent    

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Progress and Prospect of Seafloor Instability Research

Gao Weijian, Li Wei

Strategic Study of CAE 2023, Volume 25, Issue 3,   Pages 109-121 doi: 10.15302/J-SSCAE-2023.03.010

Abstract:

Seafloor instability and secondary submarine geohazards are widely presentHowever, formation mechanisms and controlling factors of seafloor instability are still poorly understoodTo improve the understanding, based on the history and development of seafloor instability, thisengineering geohazards risks, and summarizes popular quantitative analysis methods for seafloor instability, this study proposed the development direction and countermeasures of future seafloor instability

Keywords： seafloor instability     submarine geohazards     formation mechanisms     risk assessment     instability analysis    

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GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

Horticultural crops are a major source of high value nutritious food, and new improved cultivars developed through breeding are required for sustainable production in the face of abiotic and biotic stresses, and to deliver novel, premium products to consumers. However, grower confidence in the performance of new germplasm, particularly across environmental variability, is important for commercial adoption and germplasm-environment matching to optimize production.

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GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE

Frontiers of Agricultural Science and Engineering   Pages 353-355 doi: 10.15302/J-FASE-2021387

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine doi: 10.1007/s11684-023-1008-8

Abstract: Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequentHowever, knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely

Keywords： 3D genome     cancer     TADs     loop     gene regulation    

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Detection of genomic signatures for pig hairlessness using high-density SNP data

Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 307-313 doi: 10.15302/J-FASE-2014039

Abstract: We conducted a genomic scan for genetically differentiated regions between hairy and hairless pigs usingA total of 38405 SNPs in 498 animals from 36 diverse breeds were used to detect genomic signatures for

Keywords： hairlessness     pig     selective sweeping    

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Size-dependent Elastic Instability of Gel CylinderWith Surface Stress

Huang Dianwu,Qiao Ling, Wang Shiji

Strategic Study of CAE 2007, Volume 9, Issue 4,   Pages 50-54

Abstract:

The elastic instability of a gel cylinder was researched with classicalThe non-classic boundary condition of the elastic instability has been educed by the energy functional So a criterion equation of the elastic instability can be got.Through the analysis of the equation, it is found that the elastic instability is relevant to the radius

Keywords： gel cylinder     elastic instability     intrinsic scale     surface effect    

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Modulational Instability of Optical Vortices in Engineered Saturable Media Review

D.G. Pires, N.M. Litchinitser

Engineering 2022, Volume 17, Issue 10,   Pages 31-43 doi: 10.1016/j.eng.2022.04.022

Abstract:

Propagation of light beams in turbid media such as underwater environments, fog, clouds, or biological tissues finds increasingly important applications in science and technology, including bio-imaging, underwater and free-space communication technologies. While many of these applications traditionally relied on conventional, linearly polarized Gaussian beams, light possesses many degrees of freedom that are still largely unexplored, such as spin angular momentum (SAM) and orbital angular momentum (OAM). Here, we present nonlinear light–matter interactions of such complex light beams with "rotational" degrees of freedom in engineered nonlinear colloidal media. By making use of both variational and perturbative approach, we consider non-cylindrical optical vortices, elliptical optical vortices, and higher-order Bessel beams integrated in time (HOBBIT) to predict the dynamics and stability of the evolution of these beams. These results may find applications in many scenarios involving light transmission in strongly scattering environments.

Keywords： Optical vortex     Orbital angular momentum     Modulation instability     Turbid media    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristicsCollectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 280-288 doi: 10.1007/s11684-017-0580-1

Abstract: occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomicHowever, few studies have investigated the genomic variations that occur only in normal tissues thatWe then called genomic variations specific to the normal lung tissues through filtering the genomic sequenceSixteen genomic variations were called in the three normal lung tissues.Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be

Keywords： lung cancer     counterpart normal control     genomic variations    

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Underlying mechanism of the hydrothermal instability of Cu

Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 103-107 doi: 10.1007/s11705-015-1552-0

Abstract: Water induced decomposition of Cu (BTC) (BTC= benzene-1,3,5-tricarboxylate) metal-organic framework (MOF) was studied using dynamic water vapour adsorption. Small-angle X-ray scattering, Fourier transform infrared spectroscopy and differential scanning calorimetry analyses revealed that the underlying mechanism of Cu (BTC) MOF decomposition under humid streams is the interpenetration of water molecules into Cu-BTC coordination to displace organic linkers (BTC) from Cu centres.

Keywords： hydrothermal stability     metal-organic framework (MOF)     open metal sites (OMSs)     dynamic water vapour adsorption    

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Title Author Date Type Operation

Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Journal Article

Combustion instability detection using the wavelet detail of pressure fluctuations

JI Junjie, LUO Yonghao

Journal Article

Progress and Prospect of Seafloor Instability Research

Gao Weijian, Li Wei

Journal Article

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Journal Article

GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS: PROMISES, PROGRESS, CHALLENGES AND OUTLOOK

Craig HARDNER, Satish KUMAR, Dorrie MAIN, Cameron PEACE

Journal Article

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Journal Article

Detection of genomic signatures for pig hairlessness using high-density SNP data

Ying SU,Yi LONG,Xinjun LIAO,Huashui AI,Zhiyan ZHANG,Bin YANG,Shijun XIAO,Jianhong TANG,Wenshui XIN,Lusheng HUANG,Jun REN,Nengshui DING

Journal Article

Size-dependent Elastic Instability of Gel CylinderWith Surface Stress

Huang Dianwu,Qiao Ling, Wang Shiji

Journal Article

Modulational Instability of Optical Vortices in Engineered Saturable Media

D.G. Pires, N.M. Litchinitser

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Journal Article

Underlying mechanism of the hydrothermal instability of Cu

Nadeen Al-Janabi,Abdullatif Alfutimie,Flor R. Siperstein,Xiaolei Fan

Journal Article